Tegelased 3

Observational Infant Exploratory [14C] Paracetamol Pharmacokinetic Microdose / Therapeutic Dose Study With Accelerator Mass Spectrometry Bioanalysis

Description: Aim was to compare [14C] paracetamol ([14C]PARA) paediatric pharmacokinetics (PK) after administration mixed in a therapeutic dose or an isolated microdose. To further develop and validate Accelerator Mass Spectrometry (AMS) bioanalysis in the 0-2 year old age group.[14C] PARA concentrations in 10-15 μl plasma samples were measured after enteral or IV administration of a single [14C] PARA microdose or mixed in with a therapeutic dose in infants receiving PARA as part of their therapeutic regimen.

  • ERANET-Priomedchild;
  • ETF

  • EUDRA-CT: No


    • Alder Hey Children's NHS Foundation Trust, Liverpool, UK; 
    • Garner Consulting, York, UK; 
    • Centre for Drug Safety Science, University of Liverpool, UK; 
    • Instytut Farmaceutyczny, Warsaw, PL; 
    • TNO Zeist, NL; 
    • University of Tartu, EE; 
    • Liverpool Women’s NHS Foundation Trust, UK

    Project's status: Finished

    Tegelased 3